Huub van Rossum
PhD, EuSpLM
Netherlands Cancer Institute
The Netherlands
Huub van Rossum is a specialist in laboratory medicine and clinical chemistry at the Netherlands Cancer Institute. He has a background in analytical chemistry and pharmaceutical sciences and followed his training for becoming a specialist in laboratory medicine in The Bronovo hospital in The Hague, Leiden University Medical Center (Netherlands) and Stanford Medical Center (USA). Next he briefly worked for about a year in the University Medical Center before in Utrecht on the implementation of best practice Quality Control. Since 2014 Huub van Rossum works as a laboratory specialist in the Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital in Amsterdam. Here he is responsible, for routine clinical diagnostics including (immune)chemistry testing and ICT. In 2014 he founded Huvaros (www.huvaros.com) that markets the MA Generator system and in 2020 he co-founded SelfSafeSure Blood Collection B.V. that aims to markets the Topper blood self-collection technology. His current research focuses on (patient-based real-time) quality control and assurance, the diagnostic validation of longitudinal (tumor) biomarkers, tumor marker harmonization, sensitive steroid analysis using LC-MS for breast and prostate cancer and implementation of all of these in routine clinical practice. Furthermore, Huub van Rossum founded and chairs the International Federation of Clinical Chemistry (IFCC) working group on global tumor marker harmonization (IFCC WG-TMH), is a board member of the International Society of Oncological and Biomarkers (ISOBM) and member of the medical staff board of the Netherlands Cancer Institute – Antoni van Leeuwenhoek hospital in Amsterdam. Huub van Rossum has (co-)authored over 80 peer-reviewed scientific manuscripts.
Aiheet
Patient-Based Real-Time QC; towards clinical implementation
Quality in Laboratory Medicine
Analytical Quality Control
5.2.2026 13:20 - 13:55 | Hall 208
n the last couple of years new insights in the understanding and practical application of Patient-Based Real-Time Quality Control (PBRTQC have been obtained. Patient-based real-time QC are quality assurance tools available at clinical laboratories that can be used to support the (analytical) quality assurance on medical laboratories. These tools include patient moving averages (MA QC) approaches in which obtained results are averaged with any kind of algorithm and used as quality control measure and checks performed on obtained results (limit, delta, and multivariate-checks) that are generally part of the auto-validation procedures. MA QC differs in several ways from statistical internal QC and combining both techniques allows improved analytical quality assurance and a more (cost-)efficient QC plan. Challenges for laboratories are how to obtain proper laboratory specific settings, how to intergrade these new techniques with standard QC and how to operate MA QC in routine practice. Recently, tools and documentation that addresses these issues has become available for medical laboratories, amongst others via an IFCC working group. This talk will briefly overview these recent developments, increase the understanding and potential application of MA QC techniques and to provide guidance when interested in implementing MA QC on medical labs.
